[Ethanol elimination in rats with different levels of alcoholic motivation]. / Eliminatsiia étanola u belykh krys s razkichnym urovnem alkogol'noi motivatsiia.

It has been established during intraperitoneal and oral administration of ethanol to white rats in a test dose of 1 g/kg that in the animals with high alcoholism motivation, the rate of alcohol elimination from blood is fairly high, while the species with low alcoholic motivation are marked by a slower ethanol elimination. In rats with high alcohol motivation, the time of ethanol anesthesia significantly exceeds that in the animals with low alcoholic motivation. The blood levels of ethanol at the moment of wake up are identical in both groups. A conclusion is made about the relationship between the elimination pattern, activity of alcohol-metabolizing enzymatic systems and predisposition to alcoholism.

[Correlation between the distribution of triftazin in certain organs of rats and its pharmacological effects when administered by different methods]. / O sootnoshenii mezhdu raspredeleniem triftazina v nekotorykh organakh krys i ego farmakologicheskimi éffektami pri raznykh sposobakh

Correlation between the dynamics of triftazine (stelazine, trifluoperazine) distribution in the brain, liver, and blood plasma of rats and the dynamics marking the development of cataleptic and antiagressive effects and also upset motor conditionation was studied. It was found that following oral administration of triftazine it slowly reaches the organs, the greatest part being adsorbed in the liver. On the contrary, of its intramuscular administration is characteristic a quicker accumulation in the organs and then the level of the neuroleptic in the brain and plasma is higher and in the liver - lower than with its oral introduction. A dissimilar dynamics of triftazine in the brain explains the difference of its pharmacological effects with diverse modes of administration. When given by mouth the content of the drug in the brain is insignificant and it rises but slowly, this being matched by a correspondingly slow development of the effects of triftazine. With the intramuscular route of introduction the neuroleptic's content in the brain rapidly reaches a high level, while its pharmacological effects are characterized by a quicker development than this is the case with its oral administration.